The first approach we are evaluating is to use chitosan as a carrier for growth factors found in human plasma that promote healing. Chitosan is a biocompatible, biodegradable material that can be easily fabricated into a variety of forms, such as films, gels, and patches. Besides being an excellent carrier, chitosan has also been shown to have natural antimicrobial and wound healing properties. Human plasma contains a variety of growth factors, including epithelial growth factor (EGF), platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β), which are important for tissue repair and regeneration. The composite of chitosan and human plasma can be created to deliver these growth factors directly to the site of the wound, accelerating the healing process.

The second approach we are evaluating is to create a scaffold using chitosan and incorporate human plasma into the scaffold. The scaffold, designed to mimic the structure of natural tissue, provides a supportive framework for cells to grow and proliferate. Human plasma can be added to the scaffold to provide nutrients and growth factors to the cells, further promoting tissue regeneration.

In both approaches, the chitosan provides a supportive structure, enhances delivery specificity, improves viscosity and site adhesion, and imparts potential antimicrobial properties, while the human plasma provides growth factors and nutrients to promote healing.